I think it would be most doable but also most exhausting from 0-6 months simply b/c they can be worn, they're not mobile enough to be getting into anything, the sleep longer parts of the day, etc. Now with a 2.5 year old I try to do the majority of my important phone calls and stuff when she's napping or reserve them for one chunk of morning time when I bring out the "working toys box" (special toys that she only get shwne I have really critical stuff that I have to get done. And my DD is fairly easy-going...she just likes to be part of the phone call which doesn't always work. If I tried to work full time from home with DD there I'd be one to try and hire a mother's helper.