I assume you are talking about ductless mini-split systems?
There was a time when the AC companies were really touting ductless mini-splits as a comparable replacement for a ducted air system, but they've really backed off that claim, at least around here. The problem is the zoning. There can be a huge temperature differential between the room with the mini-split, and the nearby rooms allegedly part of the same zone. The company claim was that there zoning eliminated hot/cold spots, but the reality is that the air flow just did not live up to that promise. At least not in the south, where the AC is blasting in every room.
That being said, we have Mitsubishi mini-split in a garage, and will likely be doing some kind of mini-split in an upcoming pool house. We are happy with it. For open spaces, they work well and very efficiently. In terms of appearance, Mitsubishi makes a more modern looking unit now. And several brands have a recessed in-ceiling option. I still wouldn't call it attractive, as it essentially looks like a large bathroom vent fan. But it is less conspicuous than the wart on the wall.
One thing to keep in mind is that your regular ducted air conditioner has filters than need to be changed/cleaned periodically. The same is true of the ductless. But while you may plan for your ducted filters to be easily accessible, your ductless unit may be high on a wall. And they aren't quite as simple to open as a ducted filter housing. I have a maintenance plan with my AC company, so they handle all of that for me on a schedule. But something to consider if you are doing it all yourself.
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