Covid booster - J&J?

[hbridge]

Hi all,

So back when vaccines were hard to find, we got the J&J vaccine since that is what they had. Now it's time for boosters and the J&J vaccine is no where to be found. I need to call my doctor tomorrow and figure out the booster situation (although she told me to get it ASAP). I am thinking the Moderna booster? What are people doing/thinking?

Thanks so much.

[jgenie]

If I received J & J, I would opt for a Moderna booster.

[carolinamama]

DH got the J&J. He plans to get the Moderna this week. In our area, it's easy to find appointments at Walgreens and CVS for either Pfizer or Moderna.

[WatchingThemGrow]

Are we thinking Moderna for Pfizer people also, in addition to J&J people? And similar mixing and matching for Moderna people too?


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[AngB]

Are we thinking Moderna for Pfizer people also, in addition to J&J people? And similar mixing and matching for Moderna people too?


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I am, personally. (Healthcare in high covid area, working w high risk pregnant women, kids in mask optional school.) If our factors were less risky I would probably just do Pfizer again. I think it's good enough for most people. I would hate to get covid from my kids and then unknowingly give it to a high risk pregnant woman.)

[gymnbomb]

Are we thinking Moderna for Pfizer people also, in addition to J&J people? And similar mixing and matching for Moderna people too?


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I have been wondering this too. I saw some data comparing immune response to different boosters in those who got J&J originally (though I just realized I am unsure if that was with the full dose or half dose of Moderna as the booster). But I haven’t seen similar for those who originally got Pfizer. I will be eligible in a week, but may wait another month or two depending on my work schedule and DH’s travel schedule.


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[wencit]

I have been wondering this too. I saw some data comparing immune response to different boosters in those who got J&J originally (though I just realized I am unsure if that was with the full dose or half dose of Moderna as the booster). But I haven’t seen similar for those who originally got Pfizer. I will be eligible in a week, but may wait another month or two depending on my work schedule and DH’s travel schedule.

Here are a couple write ups from epidemiologists I follow with graphs showing the antibody boost following a Pfizer or Moderna booster after an initial Pfizer series:

https://yourlocalepidemiologist.subs...4Q7IotdiUirmO0 (look at Group 3 and Group 9 on the first figure)
https://dearpandemic.org/new-mix-and-match-data/

Essentially, Moderna looks to be slightly better, BUT with one big caveat: these trials used the full dose of Moderna (100mcg) as a booster, whereas the authorized booster is only a half dose (50mcg). Therefore, we can't really be sure how an apples-to-apples comparison of a half dose Moderna booster would compare to a full dose Pfizer booster since we don't have those numbers (bummer). However, even a half dose of Moderna is still more vaccine than a full dose of Pfizer (30mcg).

[bisous]

So...I got Pfizer but kind of want a J&J boost! TWIV was talking about how the J&J is showing more robust response in the Tcells than the other vaccines! Anyone else want that kind of "hetero" boost?

I don't think I qualify though. I'm not old enough, don't have any health conditions and I work from home. I recognize I could get any vaccine I want right now by walking into my neighborhood pharmacy but I also feel ok waiting.

[MSWR0319]

Here are a couple write ups from epidemiologists I follow with graphs showing the antibody boost following a Pfizer or Moderna booster after an initial Pfizer series:

https://yourlocalepidemiologist.subs...4Q7IotdiUirmO0 (look at Group 3 and Group 9 on the first figure)
https://dearpandemic.org/new-mix-and-match-data/

Essentially, Moderna looks to be slightly better, BUT with one big caveat: these trials used the full dose of Moderna (100mcg) as a booster, whereas the authorized booster is only a half dose (50mcg). Therefore, we can't really be sure how an apples-to-apples comparison of a half dose Moderna booster would compare to a full dose Pfizer booster since we don't have those numbers (bummer). However, even a half dose of Moderna is still more vaccine than a full dose of Pfizer (30mcg).

Thanks for sharing! I ended up getting my third Pfizer two weeks ago. I was waiting to see about mixing and matching and finally decided to just go for it because cases in our area are super high still, and it had been over 6 months since my last one. I've read articles that the third Pfizer showed 95% efficacy in trials, so that's good for me for right now. I was also a little concerned about how I would react to a Moderna vaccine, as I felt horrible with my second Pfizer. Many of my friends who had Moderna felt way worse than me and had swollen lymph nodes for months, so I wasn't sure how I would feel and at least knew how I reacted to the first round. My third Pfizer was much less than the second as far as side effects. This data makes me feel ok about my decision, that I was afraid I would regret. I may be missing out on a bit extra boost, but it doesn't look like a whole lot and I'm more protected than I was with my second.

[ang79]

Thanks for sharing! I ended up getting my third Pfizer two weeks ago. I was waiting to see about mixing and matching and finally decided to just go for it because cases in our area are super high still, and it had been over 6 months since my last one. I've read articles that the third Pfizer showed 95% efficacy in trials, so that's good for me for right now. I was also a little concerned about how I would react to a Moderna vaccine, as I felt horrible with my second Pfizer. Many of my friends who had Moderna felt way worse than me and had swollen lymph nodes for months, so I wasn't sure how I would feel and at least knew how I reacted to the first round. My third Pfizer was much less than the second as far as side effects. This data makes me feel ok about my decision, that I was afraid I would regret. I may be missing out on a bit extra boost, but it doesn't look like a whole lot and I'm more protected than I was with my second.

Interesting that your third Pfizer was not as bad as your second. A friend of mine was the opposite, she said her third shot caused her arm to swell for several days and was very sore and tired and bad headache (though she also gets frequent migraines). Her description sounded similar to what I felt for my second Modena, so I’m not looking forward to a third dose if it gets worse!


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